Chicago is known as a major global financial center and headquarters to major exchanges like CME Group and CBOE. As such, the city has cultivated a strong boutique investment banking culture. Compared to bulge bracket banks, Chicago’s boutique investment banks offer more specialized services and closer client relationships. This article will provide key insights on Evercore, Guggenheim and William Blair – three top boutique investment banks based in Chicago.

Evercore Chicago leads in technology and healthcare deals
Founded in 1995 in New York, Evercore set up its Chicago office in 2003. The Chicago team focuses on advising technology, healthcare and industrial companies. According to Refinitiv, Evercore Chicago ranked No.1 in healthcare M&A deal volume and No.4 in technology deal volume in 2021 among Midwest boutique investment banks. Key clients include Baxter, Stericycle, Motorola Solutions, etc. Evercore Chicago’s specialized expertise and independent advice make it a preferred partner for complex strategic transactions.
Guggenheim Chicago active in mid-market deals
Guggenheim Partners opened its Chicago office in 2001 after acquiring Midwest investment bank Clayton, Dubilier & Rice. Guggenheim Chicago offers M&A advisory, debt and equity capital raising, and financial restructuring services. It focuses on the technology, industrial, consumer, healthcare and financial sectors. A notable strength is advising middle-market companies, with recent deals including advising SPX FLOW on its $3.8 billion sale to Apollo-backed Lone Star Funds.
William Blair leads in SPAC listings
Founded in Chicago in 1935, William Blair is the city’s oldest and largest private investment banking firm. It provides specialized advice in healthcare/life sciences, financial/fintech, technology/media/telecom and consumer/retail sectors. William Blair has extensive expertise in taking companies public, including through SPAC listings. In 2021, it was the No. 1 advisor by deal count for de-SPAC listings in the US.
In summary, Evercore, Guggenheim and William Blair are leading boutique investment banks based in Chicago with deep expertise in healthcare, technology, industrial and consumer sectors. They differentiate through specialized offerings and strong client relationships.